In 1986, Hardy and Anderson first described the term hypereosinophilic syndrome. This syndrome is characterized by persistent and prolonged eosinophilia, with primarily hematologic, cardiac, neurologic and dermatologic abnormalities. Cutaneous
manifestations occur in 27-57% of patients. Two types of skin lesions have been noted : (1) erythematous pruritic papules and nodules or (2) urticaria and angioedema.
We report a case of hypereosinophilic syndrome with a vesicular eruption which is a rare skin lesion in this syndrome, in a 17 year old man. Diagnosis of hypereosinophilic syndrome was established by clinical findings, marked blood eosinophilia
without
a known cause, bone marrow aspiration and biopsy, liver scan and ultrasonography, and histopathologic findings of the skin.
(Kor J Dermatol 1995;33(2) : 332~338)
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